https://orcid.org/0000-0003-2348-4207
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Abstract
Purpose
Obesity is an important risk factor for nonalcoholic fatty liver disease (NAFLD). Perirenal fat and paranephric fat were seldom studied in NAFLD. We aimed to explore the relationship between perirenal fat thickness (PrFT) and paranephric fat thickness (PnFT) and NAFLD in patients with type 2 diabetes mellitus (T2DM).
Patients and Methods
A total of 493 diabetic patients including 231 NAFLD patients were enrolled in our study from September 2019 to December 2020. Patients with NAFLD were categorized into three subgroups according to the severity and fibrosis risk of NAFLD. Anthropometric indices and clinical characteristics were collected from clinical records. PrFT and PnFT were measured via ultrasound. Multivariate logistic regression analysis was used to assess the association between PrFT, PnFT and presence, severity and advanced fibrosis risk of NAFLD.
Results
Compared with non-NAFLD patients, those with NAFLD had significantly higher PrFT and PnFT. The PrFT and PnFT were independently associated with presence of NAFLD and the PrFT was independently associated with the advanced fibrosis risk of NAFLD after adjusting confounding factors.
Conclusion
The PrFT was independently associated with the presence and advanced fibrosis risk of NAFLD in patients with T2DM.
Data Sharing Statement
Data used to support the findings of this study is available from the Dong Zhao upon request.
Acknowledgments
We sincerely thank the patients who participated in our study. We thank the doctors, nurses, and medical technicians involved in blood collection and clinical parameter measurement.
Disclosure
The authors declare that there is no conflict of interest regarding the publication of this article.