Research Progress on Relationship Between Iron Overload and Lower Limb Arterial Disease in Type 2 Diabetes Mellitus

Abstract

Iron is one of the most important trace elements in life activities. It participates in a variety of important physiological processes in the body through oxidation-reduction reaction. A large number of studies show that iron overload (IO) is closely related to the progression of diabetes and its various chronic complications. However, the mechanism of iron overload in the pathogenesis of diabetes and the mechanism of iron overload in atherosclerosis (AS) are still controversial, and the relationship between iron overload and diabetic lower extremity arterial disease (LEAD) remains still unclear. Some recent reviews and original research articles suggest further studies to explain the complex relationship between iron metabolism and atherosclerosis. This article reviews the relationship between iron overload and diabetes and its relationship with LEAD, and discusses its mechanisms from various aspects, such as lipid peroxidation induced by iron overload, so as to provide clinical diagnosis and treatment ideas for diabetic lower extremity arterial disease. It is hoped that early evaluation, diagnosis and treatment of LEAD will be inspired.

Keywords:

• iron overload
• lower extremity arterial disease
• atherosclerosis
• serum ferritin
• type 2 diabetes mellitus

Data Sharing Statement

All data generated or analyzed during this study are included in this published article.

Ethics Approval and Consent to Participate

An ethics statement was not required for this study type, no human or animal subjects or materials were used.

Disclosure

None of the authors had any personal, financial, commercial, or academic conflicts of interest.

Additional information

Funding

Major projects of Wuhan Health Commission, Grant/Award Number: WG20MO1; Key projects of Hubei Provincial Department of science and technology, Grant/Award Number:2020BH B018.