Research Progress of Duodenal-Jejunal Bypass Liner in the Treatment of Obesity and Type 2 Diabetes Mellitus

Abstract

With the development of economy and improvement of people’s living standards, the incidence of obesity and type 2 diabetes mellitus (T2DM) has increased significantly and obesity has also become one of the most important risk factors of T2DM. In light of these trends, there have been many ways to take effect in losing weight. However, they also have corresponding deficiencies including inapparent curative effect, complex and incomplete reversible procedures and severe complications. Duodenal-Jejunal Bypass Liner (DJBL), which mimics Roux-en-Y gastric bypass (RYGB), is proved to play a key role in weight loss and control of T2DM. DJBL is reversible, less invasive and is more suitable for the treatment of obesity and T2DM, which is associated with multiple mechanisms, including incretin effect, gastric emptying mechanism, bile acid regulation, intestinal microbiota, inflammatory reaction mechanism and neural mechanism. In our review, we aimed to elaborate DJBL’s clinical efficacy, safety and mechanisms in detail.

Keywords:

• duodenal-jejunal bypass liner
• obesity
• type 2 diabetes mellitus
• Roux-en-Y gastric bypass

Abbreviations

Kg, kilogram; hsCRP, high-sensitivity C-reactive protein; LDL, low-density lipoprotein; CCK, cholecystokinin; TGR, Takeda G-protein-coupled receptor; TNF, tumour necrosis factor alpha; IL, interleukin; TGF, transforming growth factor.

Ethical Approval and Informed Consent Statement

Formal consent is not required for this type of study. Therefore, informed consent does not apply.

Author Contributions

H.-J.C. was responsible for the conception, design and writing of this article. H.-Z.Y. was responsible for the conception and substantial revision of this article. F.-L.Q.L. was responsible for the conception and critical review of this article. G.-Q.M. was responsible for the conception and critical review of this article. X.C. was responsible for the conception, design, critical review and substantial revision of this article. All authors have agreed on the journal to which the article will be submitted. All authors have reviewed and agreed on all versions of the article before submission, during revision, the final version accepted for publication and any significant changes introduced at the proofing stage. All authors agree to take responsibility and are accountable for the contents of the article.

Disclosure

The authors declare that they have no conflict of interest.

Additional information

Funding

This review was supported by the Science and Technology Program of Tianjin (No.21JCQNJC00990).