Triglyceride Glucose Index is Related with the Risk of Mild Cognitive Impairment in Type 2 Diabetes

Abstract

Background

The triglyceride glucose (TyG) index reflects insulin resistance; the latter being associated with mild cognitive impairment (MCI).

Objective

To investigate the clinical value of the TyG index to identify MCI in patients living with type 2 diabetes (T2D) using a cross-sectional study.

Methods

This cross-sectional study was performed on 517 patients with T2D. The diagnosis of MCI was based on criteria established by the National Institute on Aging-Alzheimer’s Association workgroup, and patients were divided into the MCI group and the normal cognitive function (NCF) group. The logistic regression analysis determines whether the TyG index is related to MCI. Subsequently, we constructed the receiver operating characteristic curve (ROC) and calculated the area under the curve (AUC). The nomogram model of the influence factor was established and verified.

Results

Compared to the type 2 diabetes-normal cognitive function (T2D-NCF) group, the MCI subjects were olderand had higher TyG indexes, lower cognitive scores, and lower education levels (p < 0.01). After adjusting for the confounders, the TyG index was associated with MCI (OR = 7.37, 95% CI = 4.72–11.50, p < 0.01), and TyG-BMI was also associated with MCI (OR = 1.02, 95% CI = 1.01–1.02, p<0.01). The TyG index AUC was 0.79 (95% CI = 0.76–0.83). The consistency index of the nomogram was 0. 83[95% CI (0. 79, 0. 86)].

Conclusion

Our results indicate that the TyG index and TyG-BMI are associated with MCI in T2D patients, and the TyG index is an excellent indicator of the risk of MCI in T2D patients. The nomogram incorporating the TyG index is useful to predict MCI risk in patients with T2D.

Keywords:

• triglyceride glucose index
• TyG
• mild cognitive impairment
• MCI
• insulin resistance
• IR
• type 2 diabetes
• T2D

Data Sharing Statement

The datasets generated and/or analyzed during the current study are not publicly available due to [REASON WHY DATA ARE NOT PUBLIC] but are available from the corresponding author on reasonable request.

Ethics Approval and Consent to Participate

This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of the First Affiliated Hospital of Harbin Medical University.

Consent for Publication

Informed consent was obtained from all individual participants included in the study.

Acknowledgments

Thanks to all authors for their efforts and participants for their understanding and support of our study.

Disclosure

The authors report no conflicts of interest in this work.

Additional information

Funding

This work was supported by a grant from the Fund of Scientific Research Innovation of the First Affiliated Hospital of Harbin Medical University [grant number 2020M27, China].