Genetic Susceptibility to Chronic Kidney Disease: Links, Risks and Management

Abstract

Chronic kidney disease (CKD) is associated with significant morbidity and mortality worldwide. In recent years, our understanding of genetic causes of CKD has expanded significantly with several renal conditions having been identified. This review discusses the current landscape of genetic kidney disease and their potential treatment options. This review will focus on cystic kidney disease, glomerular disease with genetic associations, congenital anomalies of kidneys and urinary tract (CAKUT), autosomal dominant-tubulointerstitial kidney disease (ADTKD), inherited nephrolithiasis and nephrocalcinosis.

Keywords:

• genetics
• chronic kidney disease
• end stage kidney disease
• cystic kidney disease

Acknowledgments

The authors would like to thank Dr. Leal Herlitz, Director of Medical Kidney Pathology at Cleveland Clinic Ohio, for graciously providing pathology figures for this manuscript.

Figures 1 and 2 created using biorender.com.

Disclosure

Dr Shane A Bobart reports honorarium for Lecture from Travere Therapeutics, outside the submitted work. The authors state no conflicts of interest.

Additional information

Funding

There is no funding to report.