Ambroxol for the treatment of fibromyalgia: science or fiction?

Abstract

Fibromyalgia appears to present in subgroups with regard to biological pain induction, with primarily inflammatory, neuropathic/neurodegenerative, sympathetic, oxidative, nitrosative, or muscular factors and/or central sensitization. Recent research has also discussed glial activation or interrupted dopaminergic neurotransmission, as well as increased skin mast cells and mitochondrial dysfunction. Therapy is difficult, and the treatment options used so far mostly just have the potential to address only one of these aspects. As ambroxol addresses all of them in a single substance and furthermore also reduces visceral hypersensitivity, in fibromyalgia existing as irritable bowel syndrome or chronic bladder pain, it should be systematically investigated for this purpose. Encouraged by first clinical observations of two working groups using topical or oral ambroxol for fibromyalgia treatments, the present paper outlines the scientific argument for this approach by looking at each of the aforementioned aspects of this complex disease and summarizes putative modes of action of ambroxol. Nevertheless, at this point the evidence basis for ambroxol is not strong enough for clinical recommendation.

Keywords:

• Nav 1.8
• Nav 1.7
• bromhexine
• hyperalgesia
• sympathetically maintained pain
• central sensitization
• interleukins
• neuropathic pain
• sodium channels

Disclosure

In the past 3 years, KUK has worked as a consultant and/or speaker for the following companies (*offering ambroxol): Astellas, AstraZeneca, Bionorica, Berlin Chemie,* Boehringer Ingelheim,* Betapharm, Genzyme, Grünenthal,* Hexal,* Indivior, Kyowa Kirin, Lilly, Mundipharma,* Ratiopharm,* and Sanofi.* MS reports no conflicts of interest in this work.