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Abstract
Objectives
Delayed sleep phase syndrome (DSPS) is a chronic dysfunction of circadian rhythm of the subject that impairs functioning in social, occupational, or other spheres. High rate of depression is found among DSPS patients. Aripiprazole (APZ), a second-generation antipsychotic, is effective in treatment of depression as well as schizophrenia. Recently, few case reports show the effectiveness of APZ in treating DSPS and non-24-hour sleep–wake rhythm disorder. Therefore, we tried to treat DSPS with depression using APZ.
Methods
Twelve subjects (including four women) aged 19–64 years were included. The subjects were prescribed initially 0.5–3 mg of APZ once a day with subsequent dose adjustments.
Results
Sleep onset, midpoint of sleep, and sleep offset were significantly advanced by 1.1, 1.8, and 2.5 hours, respectively. Unexpectedly, sleep duration became significantly shorter by 1.3 hours after treatment. Their depressive moods showed an unremarkable change.
Conclusion
Low dose of APZ advanced the sleep rhythm and reduced nocturnal sleep time in the subjects with DSPS. Since it is not easy for physicians to treat prolonged sleep duration often associated with DSPS, this medication would become a new therapeutic option for these patients.
Acknowledgments
Preliminary version of this study was presented at APSS 2017 and published in Japanese (Seishinka Chiryogaku).
Disclosure
Takashi Kanbayashi has received speaker’s honoraria from Otsuka Pharmaceutical, MSD, and Eisai. Manabu Takaki has received speaker’s honoraria from Otsuka Pharmaceutical. Tetsuo Shimizu has received research grants from Eisai and MSD, and speaker’s honoraria from MSD, Takeda Pharmaceutical, Pfizer, and Yoshitomi Pharmaceutical. The authors report no other conflicts of interest in this work.