Memantine induces manic episode in a 73-year-old patient with vascular neurocognitive disorder: a case report

Jinfeng Duan1 Department of Psychiatry, First Affiliated Hospital, College of Medicine, Zhejiang University, The Key Laboratory of Mental Disorder’s Management of Zhejiang Province, Hangzhou, People’s Republic of China;2 Brain Research Institute of Zhejiang University, Hangzhou, People’s Republic of China

Chengming Lao3 College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China;4 Yiwu Mental Health Center, Yiwu, People’s Republic of China

Jingkai Chen1 Department of Psychiatry, First Affiliated Hospital, College of Medicine, Zhejiang University, The Key Laboratory of Mental Disorder’s Management of Zhejiang Province, Hangzhou, People’s Republic of China;2 Brain Research Institute of Zhejiang University, Hangzhou, People’s Republic of China

Fen Pan1 Department of Psychiatry, First Affiliated Hospital, College of Medicine, Zhejiang University, The Key Laboratory of Mental Disorder’s Management of Zhejiang Province, Hangzhou, People’s Republic of China;2 Brain Research Institute of Zhejiang University, Hangzhou, People’s Republic of China

Chenlin Zhang3 College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China

Weijuan Xu1 Department of Psychiatry, First Affiliated Hospital, College of Medicine, Zhejiang University, The Key Laboratory of Mental Disorder’s Management of Zhejiang Province, Hangzhou, People’s Republic of China;2 Brain Research Institute of Zhejiang University, Hangzhou, People’s Republic of China

Weihua Zhou1 Department of Psychiatry, First Affiliated Hospital, College of Medicine, Zhejiang University, The Key Laboratory of Mental Disorder’s Management of Zhejiang Province, Hangzhou, People’s Republic of China;2 Brain Research Institute of Zhejiang University, Hangzhou, People’s Republic of China

Jianbo Hu1 Department of Psychiatry, First Affiliated Hospital, College of Medicine, Zhejiang University, The Key Laboratory of Mental Disorder’s Management of Zhejiang Province, Hangzhou, People’s Republic of China;2 Brain Research Institute of Zhejiang University, Hangzhou, People’s Republic of China

Desheng Shang1 Department of Psychiatry, First Affiliated Hospital, College of Medicine, Zhejiang University, The Key Laboratory of Mental Disorder’s Management of Zhejiang Province, Hangzhou, People’s Republic of China

Manli Huang1 Department of Psychiatry, First Affiliated Hospital, College of Medicine, Zhejiang University, The Key Laboratory of Mental Disorder’s Management of Zhejiang Province, Hangzhou, People’s Republic of China;2 Brain Research Institute of Zhejiang University, Hangzhou, People’s Republic of ChinaCorrespondence[email protected] [email protected]

Yi Xu1 Department of Psychiatry, First Affiliated Hospital, College of Medicine, Zhejiang University, The Key Laboratory of Mental Disorder’s Management of Zhejiang Province, Hangzhou, People’s Republic of China;2 Brain Research Institute of Zhejiang University, Hangzhou, People’s Republic of ChinaCorrespondence[email protected] [email protected]

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Abstract

Memantine, an N-methyl-d-aspartate receptor antagonist, is a well-established treatment option for moderate-to-severe cognitive impairment related to Alzheimer disease. Recently, growing evidence has indicated memantine might also be effective in treatment of affective disorders. The common drug-induced adverse events of memantine include confusion, dizziness, drowsiness, headache, insomnia, and agitation. Herein, we presented a case of a 73-year-old female patient with vascular neurocognitive disorder, who developed a manic episode after taking memantine.

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Acknowledgments

This work was supported by grant 2016YFC1306900 from the National Key Research and Development Program of China, grant LGF18H090003 of the Basic Public Welfare Research Projects in Zhejiang province, and grant 2015C03040 of the Key Research Project of Zhejiang Province. The funding sources had no role in the study design; collection, analysis, and interpretation of data; writing of the manuscript; or decision to submit the paper for publication.

Disclosure

The authors report no conflicts of interest in this work.

Memantine induces manic episode in a 73-year-old patient with vascular neurocognitive disorder: a case report

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Memantine induces manic episode in a 73-year-old patient with vascular neurocognitive disorder: a case report

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