Do eyes with and without optic neuritis in multiple sclerosis age equally?

Abstract

Purpose

Anterior visual pathway reflects axonal loss caused by both optic neuritis (ON) and neurodegeneration in multiple sclerosis (MS). Although the axonal injury post-ON is thought to be complete by 6 months of onset, most studies using optical coherence tomography (OCT) to evaluate retinal changes as a marker of neurodegeneration exclude eyes with a history of ON or consider them separately. The objective of this study was to assess whether the eyes post-ON (>6 months) show in later years different rate of chronic retinal changes than the fellow eyes not affected by ON.

Patients and methods

Fifty-six patients with MS with a history of ON in one eye (ON eyes) and no ON in the fellow (FL) eye, who were followed by OCT for >2 years, were selected from a cohort of patients with MS. Paired eye analysis was performed.

Results

Mean interval post-ON at baseline was 5.65 (SD 5.05) years. Mean length of follow-up by OCT was 4.57 years. There was no statistical difference in absolute or relative thinning of retinal nerve fiber layer in peripapillary area between the ON and FL eyes.

Conclusion

This study has shown that we do not need to exclude eyes with a history of ON from longitudinal studies of neurodegeneration in MS, provided that we use data outside of the frame of acute changes post-ON. Long-term changes of peripapillary retinal nerve fiber layer in ON and FL eyes are equal.

Keywords:

• optical coherence tomography
• neurodegeneration
• multiple sclerosis
• retina

Acknowledgments

Data collection and statistical analysis were supported by a research grant provided by Biogen Idec. This work was supported by the Czech Ministry of Education project PROGRES-Q27/LF1. LS also received long-term institutional support of research activities by Faculty of Informatics and Statistics, University of Economics, Prague.

Disclosure

The authors report no conflicts of interest in this work.