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Abstract
Purpose
To determine the diagnostic and localization value of 18F-fluorodeoxyglucose-positron emission tomography (PET)/computed tomography (CT) in patients with focal cortical dysplasia (FCD) who underwent epilepsy surgery.
Methods
One hundred and eight patients with pathologically proven FCD who underwent surgery for refractory epilepsy were retrospectively analyzed. All patients underwent magnetic resonance imaging (MRI), 18F-FDG-PET/CT, and video electroencephalography. An MRI diagnosis of FCD was defined as MRI+. A PET/CT diagnosis of FCD was defined as PET/CT+.
Results
MRI and PET/CT detected FCD in 20.37% and 93.52% of patients, respectively. The difference was significant. Twenty-one patients were MRI+/PET+, 80 were MRI-/PET+, six were MRI-/PET-, and one was MRI+/PET-. The MRI positivity rate was lowest in patients with FCD type IIIa (5.6%, P < 0.05). Prevalence of MRI-/PET+ was highest in patients with FCD type IIIa (88.89%, P < 0.05).
Conclusion
PET/CT is superior to MRI in detecting FCD. FCD type IIIa was more likely than other types to show MRI-/PET+. This suggests that PET/CT has particular diagnostic value for FCD type IIIa patients with negative MRI findings.
Ethical Standards
The ethics committee of the First Affiliated Hospital of Fujian Medical University has approved this study.
Informed Consent
Considering that the data was reviewed retrospectively, patient consent was not needed. Every author would comply with the Declaration of Helsinki and keep patient data confidential.
Acknowledgment
We thank our colleagues in the Department of Pathology at the First Affiliated Hospital of Fujian Medical University of China for providing histopathological diagnoses.
Disclosure
The authors have no competing interests.