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Abstract
Background and Purpose
This study aimed to investigate the impact of implementing a low-lectin diet on gut microbiota composition and symptom amelioration in pediatric patients diagnosed with Attention Deficit Hyperactivity Disorder (ADHD).
Methods
A total of 58 children (ages 7–15 years), meeting the criteria for ADHD were recruited. In addition to standard medication treatment, participants in the experimental group with a low-lectin diet, while those in the control group received standard medication treatment alone. Clinical outcomes were assessed through evaluations conducted by physicians and teachers, implementation of the Conners Parent Rating Scales, and analysis of gut microbiota composition.
Results
The results revealed significant improvements in symptom reduction and attention allocation rate within the experimental group, surpassing those observed in the control group. Specifically, the experimental group exhibited lower physician ratings, teacher ratings, and attention allocation rate compared to the control group. Moreover, analysis of gut microbiota composition identified notable distinctions between the two groups.
Conclusion
These findings provide compelling evidence and valuable guidance supporting the integration of a low-lectin diet as an adjunctive intervention for managing ADHD.
Data Sharing Statement
This study is a single-center prospective cohort study. The subjects recruited for this study were children with ADHD aged 7–15 years old. All participants underwent screening and recruitment at the Outpatient Department of the Psychiatry Department at Hunan Brain Hospital between June 2022 and March 2023. A total of 58 children with ADHD were enrolled, with 30 in the control group and 28 in the experimental group. The datasets used and/or analysed during the current study available from the corresponding author on reasonable request.
Ethics Approval and Consent to Participate
This study complies with the principles of the Declaration of Helsinki. All participants and their parents were provided with a written informed consent form after a thorough explanation of the study’s content to ensure the ethicality of the study and protect the rights of participants. This study was approved by the Ethics Committee of Hunan Brain Hospital (Approval No.: 2023K008). All methods were carried out in accordance with relevant guidelines and regulations.
Author Contributions
All authors made a significant contribution to the work reported, whether that is in the conception, study design, execution, acquisition of data, analysis and interpretation, or in all these areas; took part in drafting, revising or critically reviewing the article; gave final approval of the version to be published; have agreed on the journal to which the article has been submitted; and agree to be accountable for all aspects of the work.
Disclosure
The authors report no conflicts of interest in this work.