Clinical evaluation of the therapeutic effects of atelocollagen absorbable punctal plugs

Abstract

Purpose

To evaluate the therapeutic effects of atelocollagen absorbable punctal plugs.

Method

Seventy-four eyes in 37 patients with dry eye disease (DED) underwent punctal plug occlusion using atelocollagen plugs and were followed up for 24 weeks. Subjective symptoms were evaluated using the ocular surface disease index (OSDI) questionnaire. Ocular surface disease parameters, including the Schirmer test, phenol red thread test, tear break-up time (TBUT), and fluorescein and Rose Bengal staining, were recorded before and 1, 4, 8, 16, and 24 weeks after treatment.

Results

In comparison with the pretreatment data, the subjective symptoms and ocular surface disease parameters showed significant improvement after atelocollagen punctal occlusion. The average time of relapse was 17.4 ± 5.1 weeks. No severe complications occurred, and none of the plugs had to be removed because of local discomfort or epiphora.

Conclusion

Atelocollagen absorbable punctal plugs effectively improved ocular surface disorders in DED. These plugs are a safe and effective alternative in the treatment of DED.

Keywords:

• atelocollagen
• absorbable punctual plug
• dry eye

Disclosures

The authors report no conflicts of interest in this work. There was no financial support and the authors have no proprietary interest in the materials used in this study.