Cytomegalovirus retinitis treated with valganciclovir in Wegener’s granulomatosis

Abstract

A case of cytomegalovirus (CMV) retinitis in a patient with Wegener’s granulomatosis treated with oral valganciclovir as maintenance therapy is reported. A 68-year-old male patient with anti-proteinase-3 ANCA-positive Wegener’s granulomatosis who was receiving immunosuppressive therapy with methylprednisolone, cyclophosphamide, and azathioprine developed CMV retinitis. The patient received intravenous ganciclovir as induction therapy and oral valganciclovir as maintenance therapy. The patient responded to treatment and showed no recurrence for 8 months. There were no serious adverse effects associated with oral valganciclovir. Oral valganciclovir is convenient and effective for the management of CMV retinitis in the patient with Wegener’s granulomatosis.

Keywords:

• cytomegalovirus retinitis
• Wegener’s granulomatosis
• valganciclovir
• ganciclovir
• maintenance therapy

Acknowledgments

The authors are grateful to Keita Hirano and the staff of the Department of Internal Medicine, Jikei University School of Medicine, Katushika Medical Center.

Disclosure

The authors have no proprietary or commercial interest in any of the materials discussed in this work.