Wear Experiences with Two Soft Contact Lenses for Astigmatism of Different Modalities

Abstract

Introduction

Patients expect to have excellent vision and comfort when wearing soft contact lenses. The purpose of this study was to compare the wear experiences of participants with astigmatism when wearing a daily disposable soft toric lens to an established, commonly used reusable toric lens.

Methods

In this crossover study, habitual soft toric lens wearers were fit with a daily replacement soft toric lens (delefilcon A) and a reusable, 1-month replacement soft toric lens (comfilcon A) in a randomized order. After 30 days of wear, Visual analog scale (VAS) surveys were used to assess wear experience, including vision and comfort, for overall wear and end-of-day wear. Scores were compared statistically with mixed-effects linear models. Participants also responded to questions about convenience, ease of use, and satisfaction with both lenses and preference questions based upon comfort, vision, and overall performance.

Results

Fifty-nine participants completed the multi-site crossover study. VAS scores [mean(std dev)] for overall quality of vision for the delefilcon A [80.4(16.4)] and comfilcon A [66.8(27.7)] lenses were statistically significant (P=0.002). The difference in the mean overall comfort scores for the delefilcon A lenses [71.6(26.3)] and comfilcon A lenses [63.2(28.9)] was 8.4, which exceeds the establish criteria for clinical significance, although not statistically significant (P=0.08). Overall satisfaction scores were 68.8(26.9) for the delefilcon A and 59.7(30.3) for the comfilcon A lenses (P=0.08). Both lenses provided mean binocular visual acuities better than 20/20 Snellen equivalent. Over half of the participants preferred the delefilcon A lenses based upon comfort, vision, and overall performance. Convenience, ease of use, and satisfaction all scored higher with delefilcon A lenses.

Conclusion

The results of this study show that wear experience with delefilcon A lenses for astigmatism can meet or exceed that of comfilcon A toric lenses while also providing healthy, daily disposable lens wear.

Keywords:

• soft contact lenses
• astigmatism
• toric contact lenses
• comfort
• experience

Data Sharing Statement

Data reported in this manuscript are available within the article. Study-level data including the study protocol are available. To request access to the data, the researcher must sign a data use agreement. All proposals should be directed to Jennifer Swingle Fogt ([email protected]) for up to 36 months following article publication.

Acknowledgments

Funding for this investigator-initiated trial was provided by Alcon, Inc., Fort Worth, TX, USA. The project described was supported in part by Award Number Grant UL1TR002733 from the National Center for Advancing Translational Sciences. The study was designed and conducted by the authors. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Center for Advancing Translational Sciences or the National Institutes of Health.

The authors would also like to acknowledge the diligent work of Emma Grant and Spencer Mandel in coordinating this three-site study.

Disclosure

Dr Jennifer Fogt reports grants from Alcon, Inc, Vyluma, Bausch + Lomb, Cooper Vision, Interojo, VizionFocus, Eyenovia; personal fees from Envision Biomedicals, and TearOptix, outside the submitted work. Dr Katherine Bickle reports compensation from Alcon for clinical site, during the conduct of the study; clinical investigator for Johnson and Johnson Vision Care, and CooperVision, outside the submitted work. Dr Gina Wesley reports contract works for Johnson and Johnson, Coopervision, Bausch & Lomb, and Alcon, outside the submitted work. The authors report no other conflicts of interest in this work.