The Relationship Between MMP17 Variants and Ischemic Stroke Risk in the Population from Shaanxi Province in China

Abstract

Background

Ischemic stroke (IS) was a multifactorial disease, which was the main cause of death and adult disability. Genetic factors cannot be ignored.

Objective

The present study discussed the relationship between MMP17 variants and the susceptibility of IS.

Methods

Based on the Agena MassARRAY platform, we genotyped single nucleotide polymorphisms (SNPs) on the MMP17 gene in 1345 participants (670 controls and 675 cases). We used logistic regression analysis to analyze the association of MMP17 SNPs with the risk of IS in the Chinese population, with odds ratio (OR) and 95% confidence intervals (CIs). False-positive report probability (FPRP) detected false positives on the significant results. Besides, we detected the SNP–SNP interaction to predict IS risk by multi-factor dimensionality reduction (MDR) analysis.

Results

In the total analysis, MMP17 rs7975920 conferred an increased susceptibility to IS. After a stratified analysis by age and gender, the significant association between rs7975920 and IS risk was displayed in the subjects aged >55 years old and females. After stratified analysis by smoking and drinking, MMP17 rs6598163 was related to the risk of IS in smokers and rs7975920 was associated with the risk of IS in smokers and was in correlation with IS risk in drinkers.

Conclusion

In short, we first observed that MMP17 rs7975920 and rs6598163 were related to the risk of IS. The above results provided a theoretical basis for the elaboration of the role of MMP17 in IS in the Chinese population.

Keywords:

• ischemic stroke
• MMP17
• single nucleotide polymorphisms
• population

Data Sharing Statement

The datasets generated and analyzed during the current study are available from the corresponding author on reasonable request.

Ethics Approval and Informed Consent

This study was approved by the ethics Committee of Xi′an No.3 Hospital (Ethical approval No.: SYXSLL-2019-034), and all participants provided written informed consent.

Consent for Publication

All authors agree to publicize the paper.

Acknowledgments

We thank all authors for their contributions and supports. We are also grateful to all subjects for providing blood samples.

Disclosure

The authors report no conflicts of interest in this work.

Additional information

Funding

The study was supported by Natural Science Foundation of China (NO.82104155), Key Research and Development Program of Shaanxi (No.2020ZDLSF04-03 and 2021SF-096) and Xi′an Science and Technology Planning Project (21YXYY0038 and 21YXYJ0004).