Abstract
Background
Glioma is the main pathological subtype of brain tumors with high mortality.
Objective
This study aimed to elucidate the correlation between TREM1 variants and glioma risk in the Chinese Han population.
Methods
Genotyping of six variants of TREM1 was completed by Agena MassARRAY platform in 1061 subjects (503 controls and 558 glioma patients). The relationship between TREM1 polymorphisms and glioma risk was calculated using the logistic regression model, with odds ratio (OR) and 95% confidence intervals (CIs). A multifactor dimensionality reduction (MDR) method was performed to assess SNP–SNP interactions to predict glioma risk.
Results
In this research, overall analysis illustrated an association between TREM1 rs9369269 and an increased risk of glioma. Rs9369269 was also related to the risk of glioma in patients aged ≤40 years and females. Subjects with rs9369269 AC genotype were likely to obtain glioma compared to people with CC genotype (patients with astroglioma vs healthy people). Compared to TT genotype carriers, carriers with AT genotype of rs1351835 were significantly associated with overall survival (OS).
Conclusion
Taken together, the study identified the association between TREM1 variants and glioma risk and TREM1 variants were significantly associated with the prognosis of glioma. In the future, larger samples are needed to verify the results.
Data Sharing Statement
The data sets generated and analyzed during the current study are available from the corresponding author on reasonable request.
Ethics Approval and Informed Consent
Our research was approved by the ethics committee of the Xi’an Chang’an District Hospital and Northwest University, and all participants signed informed consent.
Acknowledgments
The authors thank the staff of Xi’an Chang’an District Hospital for their help in providing samples. The authors would also like to thank Dr Wenqian Zhou for her contributions in this study.
Disclosure
The authors have declared that they have no conflicts of interest in this work.