Abstract
Background
Long noncoding RNAs (LncRNAs) have been revealed to involve in cervical cancer (CC) developing. The current study was designed to explore the association of SNPs (rs217727, rs2366152, rs1859168, rs10505477) located in the lncRNA H19, HOTAIR, HOTTIP and CASC8 genes with the risk of CC in a Chinese Han population.
Methods
Four SNPs were selected and genotyped in 1426 participants (274 CIN patients, 448 CC patients, and 704 healthy control individuals) using MassArray. The association of these SNPs with susceptibility to CC was evaluated.
Results
Significant differences in allelic distribution of rs217727 were observed in the comparison of CC with control (P = 0.001), indicating the risk of rs217727-A allele in CC (OR = 1.33; 95% CI: 1.12–1.58). The inheritance model analysis revealed that 2AA+GA genotype represented a certain risk of CC (P = 0.001, OR = 1.35; 95% CI: 1.13–1.62). The stratified analysis revealed a risk of the rs217727-A allele for cervical squamous cell carcinoma (SCC) (P = 0.002, OR = 1.33; 95% CI: 1.11–1.60).
Conclusion
rs217727 in lncRNA H19 exhibited a significant correlation with CC susceptibility, particularly SCC, and A/A genotype of this SNP might present as a risk in CC.
Data Sharing Statement
The original contributions presented in the study are included in the article; further inquiries can be directed to the corresponding author Chuanyin Li.
Acknowledgments
Thanks are due to Dr. Yufeng Yao for the valuable work in formal analysis and writing review and editing. The funding projects that supported the current study are gratefully acknowledged: the CAMS Innovation Fund for Medical Sciences (CIFMS) (2021-I2M-2-004), National Science Foundation of China (82103190); Association Foundation Program of Yunnan Provincial Science and Technology Department and Kunming Medical University (202201AY070001-139); Yunnan Province Clinical Research Center for Gynecological and Obstetric Disease (2022YJZX-FC04/05/06). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.
Author Contributions
All authors made substantial contributions to conception and design, acquisition of data, or analysis and interpretation of data; took part in drafting the article or revising it critically for important intellectual content; agreed to submit to the current journal; gave final approval of the version to be published; and agree to be accountable for all aspects of the work.
Disclosure
The authors declare no conflicts of interest in this work.