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Abstract
Purpose
Pandemic-related confinement helps to contain the transmission of the novel coronavirus disease (COVID-19) but restricts children’s exposure to sunlight, thereby possibly affecting their 25-hydroxyvitamin D [25(OH)D] levels. This study aimed to examine the effect of COVID-19 measures on 25(OH)D levels in children.
Patients and Methods
This study included children who underwent health checks between March 1 and June 30, 2020, and those over the equivalent period during 2017–2019 (N = 3600). Children’s 25(OH)D levels and the proportion of children with vitamin D deficiency were compared between different observation periods.
Results
The mean serum 25(OH)D level was 84 ± 25nmol/L. The overall proportion of children with vitamin D deficiency (25(OH)D level <50 nmol/L) was 4.6%. Home confinement led to an increase in the proportion of children aged 3–6 years with vitamin D deficiency during March 1–June 30, 2020 compared with the same months in previous years, and the most noticeable increase was found in March 2020. In children aged 3–6 years, 25(OH)D levels were lower in 2020 (65 ± 17nmol/L) than during 2017–2019, and the proportion of those with vitamin D deficiency was higher in 2020 (19.0%) than in previous years. Among children aged 0.5–1 and 1–3 years, 25(OH)D levels were higher (97 ± 25 nmol/L, 91 ± 27 nmol/L), while the proportion of children with vitamin D deficiency was lower in 2020 (2.3%, 3.0%) than during 2017–2019.
Conclusion
The 25(OH)D levels tended to decrease gradually with increasing age. Reduced sunlight exposure during confinement is associated with lower 25(OH)D levels among children aged 3–6 years. Therefore, vitamin D supplementation for children aged >3 years is recommended.
Abbreviations
25(OH)D, 25-hydroxyvitamin D (vitamin D); COVID-19, coronavirus disease.
Ethics Approval and Informed Consent
Ethics approval was obtained from the Medical Research Ethics Committee of Guangdong Women and Children Hospital, Guangdong, China (No.202,001,183). This study was conducted in accordance with the principles stated in the Declaration of Helsinki. The requirement for informed consent was waived due to the retrospective nature of the study. Data were processed anonymously to ensure the privacy of patients.
Author Contributions
All authors made substantial contributions to conception and design, acquisition of data, or analysis and interpretation of data; drafted the article or revised it critically for important intellectual content; agreed to submit to the current journal; gave final approval of the version to be published; and agree to be accountable for all aspects of the work.
Disclosure
The authors declare that they have no competing interests.