Abstract
Depot Medroxy Progesterone Acetate 150 mg every 3 months was given to 231 women followed through 4 671 woman/months. The same progestogen in 300 mg dosage was given as six-monthly injections to 92 women followed through 904 woman/months. These two dosage schedules were 100% effective in fertility control, the crude drop out rate reached 33.7% and 51.0% respectively. The menstrual cycles were markedly disorganized. The re-establishment of normal menstrual and endometrial cycles and fertility after stopping therapy was reported. The effects on the genital organs, glucose tolerance, thyroid and liver function tests were studied.