Abstract
Coagulation and fibrinolytic studies were performed on 18 postmenopausal women receiving medroxyprogesterone acetate S mg a day by mouth for one month. The fibrinolytic activity in the vessel wall was determined histochemically in vein biopsy specimens and in the blood after stimulation by venous stasis.
In contrast with what is seen after oestrogen treatment the fibrinolytic activity in the vein vessel wall was unchanged. Neither were any changes found in the response of the fibrinolytic activity to venous stasis, or of the coagulation factors or components of the fibrinolytic system. The investigation thus produced no evidence of a thrombogenic effect of medroxyprogesterone acetate.