Abstract
The intra-uterine volume of 10 obstetrically normal nulliparous midtrimester patients was increased by the intra-amniotic instillation of 350 ml Macrodex. There were 2 treatment failures due to the rupturing of the fetal membranes within 2 hours of the instillation. In all the remaining 8 patients the intra-uterine pressure increased gradually, following volume increase. However, it only reached the magnitude demanded for clinical abortion in 4.