Studies of Sodium Fluoride Effects (a) On Human Otosclerotic Bone (b) On Prevention of Experimental Osteoporosis in Rats (c) Synergistic Action with Phosphates

Abstract

In newborn rats, NaF in optimal doses promotes bone calcification both by decreasing bone resorption and stimulating calcium deposition. Sodium fluoride also has a preventive action on heparine-induced, cortisone-induced and fracture-induced osteoporosis in 6- to 8-week-old rats, especially if given both before and after experimental fracture and combined after fracture with Na₂HPO₄ and KH₂PO₂. Both the above results were observed by the semi-quantitative evaluation of tetracycline labeling vs. microchemical calcium assays.