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Abstract
Nasal mucosa has a specific proteolytic enzyme which the author calls the “nasal fibrinolytic enzyme”. In the work described in this paper the relationship between the nasal fibrinolytic enzyme and the SK-activated enzyme in nasal mucosa and human blood serum was investigated by electrophoresis and immunoelectrophoresis. The nasal fibrinolytic enzyme was located in the neighbourhood of the β-globulin fraction. The SK-activated enzyme in nasal mucosa was strongest in the β-globulin fraction and in this respect is similar to human blood serum. The distribution pattern of the SK-activated enzyme in the nasal polyp was more closely related to the blood serum than other nasal mucosa. By immunoelectrophoresis it was found that the nasal polyp seemed to have more properties similar to blood serum than other nasal mucosa. The pathological and biochemical significance of the nasal polyp is discussed in the light of these observations.