Peroral Chromones: A New Way to Treat Allergic Rhinitis?

Abstract

Disodium chromoglycate (DSCG) is well documented in the topical treatment of allergic rhintitis. Its use does not lead to any major side effects. FPL 57579 is a new chromone compound which is well absorbed after oral administration. In a clinical trial, patients with allergic rhinitis underwent a nasal challenge before and after ingestion of FPL 57579. The effect on nasal airway resistance (NAR) was determined by rhinomanometry. In all cases there was a smaller increase in NAR after the intake of FPL 57579.