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Original Article

Cochlear Electrical Activity in the C57BL/6 Laboratory Mouse: Volume-Conducted Vertex and round Window Responses

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Pages 61-68 | Received 28 Mar 1978, Published online: 08 Jul 2009
 

Abstract

Remote (vertex-positive, volume-conducted) and local (round window, or RW) responses were simultaneously recorded from the C57BL/6 mouse. Volume-conducted responses were obtained which corresponded to the cochlear microphonic (CM), summating potential (SP), and action potential (AP), as measured at the RW. The vertex PI corresponding to the AP, had a shorter latency to rarefaction than to condensation clicks. At higher SPL's bimodal PI peaks (a and b) were observed. PIb amplitudes were greater at lower, and PIa amplitudes were greater at higher SPL's. Responses subsequent to the RW N1 and the volume-conducted PI were eliminated after the ear was isolated from the brainstem.

ZUSAMMENFASSUNG

An der Maus C57BL/6 wurden gleichzeitig entfernte Antworten (vertex-positiv, quantitativ erfast) und örtlich Antworten (rundes Fenster RW) registriert. Die durch Quantitativerffassung erhaltenen Antworten entsprechen, jeweils am RW gemessen, dem Cochlearmikrophonpotential (CM), dem Summenaktionspotential (SP) und dem Aktionspotential (AP), Die Vertex PI reagierte bezüglich AP auf Rarefaktionssignale mit geringerer Trägheit als auf Kondensationssignale. Bei höheren SPL-Werten wurden biomodal PI-Spitzen (a und b) beobachtet. Während sich die PIb-Amplituden bei niedrigeren SPL-Werten vergröserten, nahmen die PIa-Amplituden bei höheren SPL-Werten zu. Nach Abtrennung des Ohres vom Gehirnstamm wurden die Antworten, die RW N1 und der quantitativ erfasten P1 folgten, unterbrochen.

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