The Effect of Urea and Mannitol on Cochlear Blood Flow

H. C. Larsen Department of Otolaryngology, University of Uppsala, Uppsala, Sweden; Department of Physiology, University of Uppsala, Uppsala, Sweden

C. Angelborg Department of Otolaryngology, University of Uppsala, Uppsala, Sweden; Department of Physiology, University of Uppsala, Uppsala, Sweden

E. Hultcrantz Department of Otolaryngology, University of Uppsala, Uppsala, Sweden; Department of Physiology, University of Uppsala, Uppsala, Sweden

Abstract

The cochlear and cerebral blood flows were investigated in albino rabbits with the microsphere method, both before and after intravenous injection of hyper-osmotic solutions of urea or mannitol. A significant increase in blood flow was recorded in both the inner ear and the brain. The discrepancies in the effects on blood flow and on hearing in patients with Meniere's disease provided by urea and mannitol are discussed.

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The Effect of Urea and Mannitol on Cochlear Blood Flow

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The Effect of Urea and Mannitol on Cochlear Blood Flow

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