The Release of Histamine from the Pars Flaccida Mast Cells One Cause of Otitis Media with Effusion?

Per E. Aim Division of Experimental Medicine, National Defence Research Institute, Department 4, Umeå, Sweden; the Departments of Anatomy, Histology and Otolaryngology, University of Umeå, Umeå, Sweden

Gunnar D. Bloom Division of Experimental Medicine, National Defence Research Institute, Department 4, Umeå, Sweden; the Departments of Anatomy, Histology and Otolaryngology, University of Umeå, Umeå, Sweden

Sten Hellström Division of Experimental Medicine, National Defence Research Institute, Department 4, Umeå, Sweden; the Departments of Anatomy, Histology and Otolaryngology, University of Umeå, Umeå, Sweden

Bengt Salén Division of Experimental Medicine, National Defence Research Institute, Department 4, Umeå, Sweden; the Departments of Anatomy, Histology and Otolaryngology, University of Umeå, Umeå, Sweden

Lars-Eric Stenfors Division of Experimental Medicine, National Defence Research Institute, Department 4, Umeå, Sweden; the Departments of Anatomy, Histology and Otolaryngology, University of Umeå, Umeå, Sweden

Abstract

In this experimental study in the rat, compound 48/80-a potent degranulating drug of mast cells-was instilled in the external auditory meatus towards the tympanic membrane. Moreover, effusion material was produced in the attic space by blocking the tympanic isthmus with a piece of Gelfoam applied through the tympanic bulla. Both these procedures caused a degranulation of the pars flaccida mast cells and subsequently histamine was detected in the rinsing fluid collected from the middle ear cavity. A possible direct cause of the effusion material in the middle ear cavity may be a degranulation of the pars flaccida mast cells, thus resembling an allergic reaction Type I.

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The Release of Histamine from the Pars Flaccida Mast Cells One Cause of Otitis Media with Effusion?

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