Studies on Experimental Exanthema in Rabbits by Means of Recurrent Systemic Sensitization

Abstract

To explore the relationship between the tonsils and pustulosis palmaris et plantaris, the author performed several experiments. Since, in the pustulosis palmaris et plantaris abscess, many pleomorphic leukocytes are seen histologically, in order to provoke this condition, sensitized lymphocytes isolated from sensitized rabbits were transferred intravenously. To localize the site of immunological reaction on the skin, extracts were used from cutaneous abscesses elicited by intracutaneous injection of BCE, CA, and PPD, emulsified with FCA. The results were as follows: (1) exanthema was demonstrated in 4 out of 28 rabbits; (2) the antigens that caused exanthema were BCE and CA; (3) the sites on which exanthema appeared were the footpads of both fore- and bindlimbs, in one rabbit only, and in the others, the footpads of hindlimbs; (4) as the predominant cause of the exanthema, the relationship between immune complex and sensitized lymphocytes was suspected.