Characteristics of Lymphocyte and Macrophage Reactivity in Otitis Media with Effusion

Joel M. Bernstein Departments of Otolaryngology and Pediatrics, Buffalo, New York, USA

Tatsuru Yamanaka Department of Pediatrics, State University of New York at Buffalo, Buffalo, New York, USA

James Cumella Department of Pediatrics, State University of New York at Buffalo, Buffalo, New York, USA

Pearay L. Ogra Department of Pediatrics, State University of New York at Buffalo, Buffalo, New York, USA

Abstract

On the basis of our observations and previously published data, it is proposed that in at least certain forms of chronic otitis media with effusion there is a relative predominance of macrophage-monocyte cells which are actively immunosuppressive for the proliferative response to mitogens and specific antigens, as well as for the synthesis of specific immunoglobulins. Such immunological hypo-responsiveness may be related to the patho-genesis of chronic otitis media with such effusions.

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Characteristics of Lymphocyte and Macrophage Reactivity in Otitis Media with Effusion

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Characteristics of Lymphocyte and Macrophage Reactivity in Otitis Media with Effusion

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