Bone Resorption in Cholesteatomas: An Experimental Study

P. Bretlau University ENT Department, Gentofte Hospital, Oto-Pathological Department, Rigshospitalet, Departments of Oral Diagnosis and Oral Pathology, The Royal Dental College,; Department of Pathology, Community Hospital, Copenhagen, Denmark

Chr. Hjort Sørensen University ENT Department, Gentofte Hospital, Oto-Pathological Department, Rigshospitalet, Departments of Oral Diagnosis and Oral Pathology, The Royal Dental College,; Department of Pathology, Community Hospital, Copenhagen, Denmark

M. Balslev Jørgensen University ENT Department, Gentofte Hospital, Oto-Pathological Department, Rigshospitalet, Departments of Oral Diagnosis and Oral Pathology, The Royal Dental College,; Department of Pathology, Community Hospital, Copenhagen, Denmark

E. Dabelsteen University ENT Department, Gentofte Hospital, Oto-Pathological Department, Rigshospitalet, Departments of Oral Diagnosis and Oral Pathology, The Royal Dental College,; Department of Pathology, Community Hospital, Copenhagen, Denmark

P. Holmstrup University ENT Department, Gentofte Hospital, Oto-Pathological Department, Rigshospitalet, Departments of Oral Diagnosis and Oral Pathology, The Royal Dental College,; Department of Pathology, Community Hospital, Copenhagen, Denmark

Abstract

A model for studying different aspects of human cholesteatomas in vivo in the immunodeficient 'nude' mice is described. Epithelial-mesenchymal interaction was studied in human cholesteatoma membranes, transplanted to the flank region. Findings of cystic lesions lined by stratitied keratinizing epithelium were frequent and the connective tissue reaction were weak. Furthermore human cholesteatomy membranes were transplanted into the middle ear cavity of the 'nude' mice. After 21–28 days boneresorption was shown in the labyrinthine capsule, not always with sign of inflammation.

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Bone Resorption in Cholesteatomas: An Experimental Study

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Bone Resorption in Cholesteatomas: An Experimental Study

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