Malformations of Vestibular Organs Following Low Dose Gamma Irradiation During Embryonic Development

Abstract

Pregnant mice were whole-body irradiated on the 12th, 13th and 16th gestational day with single doses of 0.5, 1, 2, 3, 4, 10 and 20 Gy, using a ⁶⁰Co source. No surviving litters occurred in groups exposed to more than 2 Gy. Below this dose, irradiation can cause malformation of the cristae ampullares and the maculae. Malformations were more severe and more frequent in fetuses exposed on the 12th than on the 13th gestational day, indicating that, prior to or the earlier during morphogenesis irradiation takes place, the more vulnerable is the developing tissue. Inner ears exposed to irradiation on the 16th gestational day did not reveal severe malformations.