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Abstract
Seventy-five children not older than 11 years, with secretory otitis media of more than 3 month's duration were randomly divided into two groups prior to myringotymy. One grup remained untreated, whereas the other received erythromycin ethylsuccinate (Abboticin™) in standard dosage for the last 10 days before surgery. Nasopharyngeal cultures were taken under general anaesthesia, which ensured an uniform mode of sampling.
In the erythromycin-treated group the occurrence of Streptococcus pneumoniae (39%) and Branhamella catarrhalis (0%) was significantly lower than in the control group (35 % and 32%, respectively): and the frequency of cultures with no pathogen was significantly higher in the treated group. The occurrence of Haemophilus influenzae remained essentially unchanged.