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Acta Oto-Laryngologica Volume 107, 1989 - Issue 5-6
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Original Article

Blood Pressure and Cochlear Blood Flow in the Guinea Pig

M. Hasegawa Department of Otorhinolaryngology, Tokyo Medical and Dental University, Tokyo, Japan
,
K. Yokoyama Department of Otorhinolaryngology, Tokyo Medical and Dental University, Tokyo, Japan
,
N. Kobayashi Department of Otorhinolaryngology, Tokyo Medical and Dental University, Tokyo, Japan
,
A. Okamoto Department of Otorhinolaryngology, Tokyo Medical and Dental University, Tokyo, Japan
,
T. Tamura Institute for Medical and Dental EngineeringTokyo Medical and Dental University, Tokyo, Japan
&
I. Watanabe Department of Otorhinolaryngology, Tokyo Medical and Dental University, Tokyo, Japan
Pages 413-416 | Published online: 08 Jul 2009
 
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Abstract

The relationship between blood pressure and cochlear blood flow was investigated in 68 guinea pigs, using the vasoactive drugs angiotensin II, norepinephrine, phentolamine, isoproterenol, dobutamine, salbutamol, propranolol, bradykinin, papaverine, vinpocetine dilazep, and brovincamine. Cochlear blood flow increases markedly and proportionately to increases in blood pressure. By contrast, cochlear blood flow shows various responses toward a fall in blood pressure. In general, cochlear blood flow appears relatively resistant to blood pressure decrease.

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