Effects of FESS and additional fluticasone propionate nasal drops on psychological well-being in nasal polyposis with asthma

Abstract

Conclusion: A combined therapy of fluticasone propionate nasal drops (FPND) and functional endoscopic sinus surgery (FESS) can improve quality of life (QoL). When compared with prior data, the results imply that a generic measure of psychological aspects of QoL may be better than measures of respiratory symptoms and clinical parameters to capture a patient's perception of the disease and its treatment. Objective: To better understand effects of FPND and FESS on generic QoL. Methods: Sixty nasal polyposis patients with concomitant asthma completed participation in a randomized, double-blind, placebo-controlled, 14-week study in which they responded to the General Well-Being Schedule (GWBS). Results: GWBS scores (i) increased significantly after administration of FPND, independent of FESS (from lower than normal to normal), (ii) increased after FESS independent of FPND (from lower than normal to normal), and (iii) increased additively after FPND and FESS.

Keywords::

• Functional endoscopic sinus surgery
• General Well-Being Schedule
• quality of life
• randomized controlled trial

Acknowledgments

Financial support for this study was provided by GlaxoSmithKline, the Swedish Association of Otorhinolaryngology, Head and Neck Surgery, the Acta Otolaryngologica Foundation, and the Swedish Asthma and Allergy Association. We wish to thank Vania Sandberg, Agneta Gülich, Ann-Sofie Lantz, Christa Elgerius, Marianne Eduards, Katarina Söderström, Karl-Gustav Kölbeck, Maria Skedinger, Barbro Dahlén, Gert Henriksson, Peter Graf, and Karin Toll for their help with this study.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this paper. After the end of this study Dr Olsson was employed by MSD, Sweden, and is presently employed by Boehringer-Ingelheim, Sweden.