Atrial natriuretic peptide modulates auditory brainstem response of rat

Abstract

Conclusion: These findings suggest that Atrial natriuretic peptide (ANP) exhibits an inhibitory effect on auditory brainstem response (ABR) and is involved in the neuromodulation of the auditory nervous system. Objectives: ANP may alter electrophysiological properties of the cochlea and play a role in auditory action. Methods: This study was undertaken to examine and clarify the role of ANP in the rat auditory system using ABR audiometry. The mean ABR thresholds and the latencies for wave II at the ABR threshold altered at given frequencies throughout the study. Results: Intra-arterial infusion of ANP (0.1 mg/kg, 4 mg/kg, and 8 mg/kg; bolus injection) resulted in a significant increase in ABR thresholds. A significant shift in the ABR wave II latency was observed at lower frequency (1 kHz and 2 kHz). There was a little change in latency at 20 kHz. Increased amount of ANP significantly altered the ABR in rats.

Keywords:

• atrial natriuretic peptide
• auditory brainstem response
• neuromodulation

Acknowledgments

This paper was supported by the research fund of Chonbuk National University and a fund of the Biomedical Research Institute, Chonbuk National University Hospital.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.