Effects of Capsaicin Desensitization on Nasal Allergy-like Symptoms and Histamine Release in the Nose Induced by Toluene Diisocyanate in Guinea Pigs

Y. Abe Departments of Otolaryngology, Osaka University Medical School, Osaka, 553, Japan

N. Takeda Departments of Otolaryngology, Osaka University Medical School, Osaka, 553, Japan

M. Irifune Departments of Otolaryngology, Osaka University Medical School, Osaka, 553, Japan

S. Ogino Departments of Otolaryngology, Osaka University Medical School, Osaka, 553, Japan

B. Kalubi Departments of Otolaryngology, Osaka University Medical School, Osaka, 553, Japan

I. Imamura Departments of Pharmacology II, Osaka University Medical School, Osaka, 553, Japan

H. Fukui Departments of Pharmacology II, Osaka University Medical School, Osaka, 553, Japan

H. Wada Departments of Pharmacology II, Osaka University Medical School, Osaka, 553, Japan

T. Matsunaga Departments of Otolaryngology, Osaka University Medical School, Osaka, 553, Japan

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Abstract

Intranasal application of toluene diisocyanate (TDI) induced nasal allergy-like symptoms of sneezing and watery rhinorrhea and decreased the histamine content of the nasal mucosa in guinea pigs. However, in the animals pretreated with capsaicin (capsaicin desensitization) before sensitization with TDI, nasal allergy-like symptoms were not induced. Capsaicin desensitization also inhibited histamine release in the nasal mucosa induced by TDI. These findings suggest that antidromic impulses of capsaicin-sensitive sensory nerves stimulated by TDI cause histamine release from mast cells in the nasal mucosa, resulting in nasal discharge and sneezing in guinea pigs. Thus neurogenic inflammation via an axon reflex in the nose may contribute to the pathogenesis of vasomotor rhinitis.

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Effects of Capsaicin Desensitization on Nasal Allergy-like Symptoms and Histamine Release in the Nose Induced by Toluene Diisocyanate in Guinea Pigs

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Effects of Capsaicin Desensitization on Nasal Allergy-like Symptoms and Histamine Release in the Nose Induced by Toluene Diisocyanate in Guinea Pigs

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