Endothelin-induced Vasoconstriction in Rabbit Nasal Mucosa

M. Benazzo Department of Otolaryngology, University of Pavia and IRCCS Policlinico S. Motteo, Pavia, Italy

A. Casasco Institute of Histology and Enihrplogy, University of Pavia, Italy

P. Lovotti Department of Otolaryngology, University of Pavia and IRCCS Policlinico S. Motteo, Pavia, Italy

A. Icaro Cornaglia Institute of Histology and Enihrplogy, University of Pavia, Italy

M. Casasco Institute of Histology and Enihrplogy, University of Pavia, Italy

J. M. Polak Royal Postgraduate Medical School, Hammersmith Hospital, University of London, UK

Abstract

Nasal blood flow is finely regulated by local release of neurotransmitters. neuropeptides and other bioactive molecules acting via paracrine mechanisms. We have investigated the effects of endothelin-l (ET-l), a potent vasoconstrictor peptide, on the blood perfusion of rabbit nasal mucosa by laser Doppler flowmetry. After injection with ET-l, a potent and prolonged nasal vasoconstriction was observed. ET-immunoreactivity has previously been detected in nasal tissues and it is therefore suggested that ET-l may participate in the regulation of nasal blood flow via paracrine mechanisms.

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Endothelin-induced Vasoconstriction in Rabbit Nasal Mucosa

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Endothelin-induced Vasoconstriction in Rabbit Nasal Mucosa

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