Role of the Prepositus Hypoglossi Nucleus on Primary Position Upbeat Nystagmus

Abstract

Electrolytical destruction of the floor of the fourth ventricle was performed on 10 cats in order to produce primary position upbeat nystagmus (PPUN). In 5 cats who had unilateral lesions of the floor of the fourth ventricle. PPUN was never seen. Two of the remaining 5 cats, who had bilateral lesions, showed PPUN. In 2 cats with PPUN, the oculomotor behavior was similar in spite of the differences in the extent of lesions. From the histological analysis in the lesions at the level of the caudal fourth ventricle, in order that PPUN may be developed, it is necessary that the prepositus hypoglossi nucleus (PH) be destroyed bilaterally. The present experiment suggests that bilateral PH lesions could result in a tonic imbalance for eye positions and eye movements of the vertical axis, resulting in a downward drift with a corrective saccade; PPUN.

Key Words:

• upbeat nystagmus
• prepositus hypoglossi nucleus
• optokinetic nystagmus
• vestibulo-ocular reflex