Association of TLR9 polymorphisms with sporadic Parkinson's disease in Chinese Han population

Abstract

Previous studies have acknowledged that inflammatory reaction has implicated in Parkinson's disease (PD) pathogenesis nowadays. Toll-like receptors (TLRs), as key players in the inflammatory reaction, play a pivotal role in the PD pathogenesis and accumulating evidences have shown that TLRs are increased in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of PD. Therefore, the present study aimed to identify the role of the polymorphisms of rs187084 and rs352140 in TLR9 gene with PD. The genotypes were detected by polymerase chain reaction and restriction fragment length polymorphism analysis in 380 PD patients and 380 healthy matched individuals in Chinese Han population. For rs352140, our data revealed a significant difference in allele distribution in female PD group and its healthy matched control (P = 0.040). Moreover, rs352140 T allele carriers of female group were associated with a reduced risk of PD (TT + TC vs. CC, P = 0.018). However, no significant differences in genotype and allele distribution were found between the age and gender subgroups for rs187084. Therefore, our studies indicate that the rs352140 gene polymorphism may be associated with the susceptibility of female PD in Chinese Han population.

KEYWORDS:

• toll-like receptors 9(TLR9)
• Parkinson^'s disease (PD)
• single-nucleotide polymorphisms (SNPs)

Acknowledgements

We are grateful to all of the subjects who kindly agreed to participate in this study.

Declaration of Interest

The authors declare that they have no conflicts of interest.

Additional information

Funding

This work was supported by the Natural Science Foundation of Shandong Province (grant number: ZR2012CM028) in China and by Chinese National Human Genome Center, Beijing.