The Selective Regional Stimulation By Hemicholinium-3 of The Formation of Cerebral Cytidine Diphosphocholine In Vivo

M. V. Gomez Michigan Neuropsychopharmacology Research Program, Department of Pharmacology, University of Michigan Medical Center, Ann Arbor, Michigan, 48104; The Mental Health Research Institute, University of Michigan Medical Center, Ann Arbor, Michigan, 48104; Department of Biochemistry, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, M.G., Brazil

O. Z. Sellinger Michigan Neuropsychopharmacology Research Program, Department of Pharmacology, University of Michigan Medical Center, Ann Arbor, Michigan, 48104; The Mental Health Research Institute, University of Michigan Medical Center, Ann Arbor, Michigan, 48104

Josephine C. Santiago Michigan Neuropsychopharmacology Research Program, Department of Pharmacology, University of Michigan Medical Center, Ann Arbor, Michigan, 48104; The Mental Health Research Institute, University of Michigan Medical Center, Ann Arbor, Michigan, 48104

E. F. Domino Michigan Neuropsychopharmacology Research Program, Department of Pharmacology, University of Michigan Medical Center, Ann Arbor, Michigan, 48104; The Mental Health Research Institute, University of Michigan Medical Center, Ann Arbor, Michigan, 48104

Abstract

Hemicholinium-3 was administered into the left ventricle of dogs and 4 hours later the left and right caudate nuclei, thalami, hippocampi and amygdala were dissected out. The specific activity of the enzyme CTP-phosphocholine cytidyltransferase (E.C.2.7.7.15) determined in homogenates of these brain structures was higher by about 40% in the left (ipsilateral) as compared to the right (contralateral) caudate nucleus, thalamus and hippocampus, while, conversely, it was about 70 % lower in the left than in the right amygdala.

The selective regional effect of hemicholinium-3 on the synthesis of cerebral cytidine disphosphocholine in vivo was confirmed at the level of the microsomes, for its specific activity was markedly higher in the fraction derived from the left than in that isolated from the right caudate nucleus.

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The Selective Regional Stimulation By Hemicholinium-3 of The Formation of Cerebral Cytidine Diphosphocholine In Vivo

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The Selective Regional Stimulation By Hemicholinium-3 of The Formation of Cerebral Cytidine Diphosphocholine In Vivo

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