Prenatal and early postnatal exposure to zimelidine: Behavioral, neurochemical and histological findings in rats

Abstract

Zimelidine (5 mg/kg/day s.c.) was administered to pregnant rats from day 10 to day 20 of gestation. The development and later open field and learning capacities of their offspring were compared to those of saline injected and untreated dams. The development and behavior of prenatally zimelidine exposed offspring resembled those of the untreated rather than the saline injected group. Pups that were nursed by zimelidine treated mothers, however, showed behavioral deficits compared to those that were nursed by saline injected dams. Prenatal or early postnatal exposure to the 5HT uptake inhibitor zimelidine did not affect 5HT uptake and release measured at 3 months of age. Histological examination of major organs of prenatally zimelidine exposed animals showed no pathological changes.

Key Words:

• zimelidine
• 5HT uptake and release
• maternal stress
• prenatal effects
• antidepressant drugs
• development
• discrimination learning
• histology