Naltrexone Suppresses Abnormal Sexual Behavior in Tourette's Syndrome

Abstract

Abnormal sexual behavior occurs in 30–40% of patients with Tourette's syndrome (TS). Two patients with TS who exhibited distressing abnormal sexual behavior experienced amelioration of symptoms with administration of the oral opiate receptor antagonist naltrexone (Trexan^R). Conventional anti-TS drugs including haloperidol and clonidine were ineffective. Abnormal sexual behavior may be another feature of the disease responding to opiate blockers.

Key Words:

• Tourette's Syndrome
• sexual behavior
• opioids
• naltrexone