Further Studies on the Effect of ASF Factor On Cl^- Permeability Across the Deiters' Neurone Plasma Membrane

M. V. Rapallino Centro di Neurofisiologia Cerebrale, C.N.R., Genova, Italy; Institute of Bacteriology and Institute of Neurobiology, University of Göteborg, Sweden

A. Cupello Centro di Neurofisiologia Cerebrale, C.N.R., Genova, Italy; Institute of Bacteriology and Institute of Neurobiology, University of Göteborg, Sweden

S. Lange Centro di Neurofisiologia Cerebrale, C.N.R., Genova, Italy; Institute of Bacteriology and Institute of Neurobiology, University of Göteborg, Sweden

I. Lönnroth Centro di Neurofisiologia Cerebrale, C.N.R., Genova, Italy; Institute of Bacteriology and Institute of Neurobiology, University of Göteborg, Sweden

H. Hydén Centro di Neurofisiologia Cerebrale, C.N.R., Genova, Italy; Institute of Bacteriology and Institute of Neurobiology, University of Göteborg, Sweden

Abstract

Experiments have been performed in order to assess whether the antisecretory factor (ASF) can influence the permeation of Cl^- ions across the Deiters' neurone plasma membrane in the outward direction. ASF is a naturally occurring, acidic protein with a molecular weight of about 60,000, which specifically inhibits enterotoxin-induced intestinal secretion. Both basal and “intracellular” GABA activated Cl^- permeability was studied, and the result confirmed the existence of GABA_A receptors on the Deiters' membrane cytoplasmic side. ASF completely abolished the effect of “intracellular” GABA on Cl^- permeability in the outward direction. However, ASF did not influence the basal Cl^- permeability in the outward direction.

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Further Studies on the Effect of ASF Factor On Cl^- Permeability Across the Deiters' Neurone Plasma Membrane