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Abstract
Forty-nine patients with multiple cerebral infarcts with a mean age of 70.2 years were studied to elucidate the effect of periventricular lucencies (PVLs) on cerebral blood flow (CBF). Patients with multiple cerebral infarcts showed significantly lower mean cortical blood flow (Fl) values compared to 15 age-matched normal subjects (p <. 01). The mean Fl values were most significantly decreased in severe group of PVLs and moderately decreased in moderate and mild groups (p <. 05 between severe and mild groups); however, no significant differences in mean Fl values were found between severe and moderate groups. Demented patients showed significantly lower Fl values compared to nondemented patients (p <. 001) and normal subjects (p <. 001). There was no significant difference in the degree of PVL between demented and nondemented groups. As well, the mean Fl values were not significantly correlated with either the number of infarcts or ventricular dilatation. These results suggest that PVLs on CT (especially in severe cases of PVLs) may have some role in the reduction of cortical blood flow in patients with multiple cerebral infarcts.