Differential Effects of Left Versus Right Seizure Focus on Human Hippocampal Evoked Responses

Kimford J. Meador Department of Neuorology, Medical College of Georgia

David W. Loring Department of Neuorology, Medical College of Georgia

Brian B. Gallagher Department of Neuorology, Medical College of Georgia

Don W. King Department of Neuorology, Medical College of Georgia

Anthony M. Murro Department of Neuorology, Medical College of Georgia

Elaine E. Thompson Department of Neuorology, Medical College of Georgia

Gregory P. Lee Department Surgery (Neurosurgery), Medical College of Georgia

Herman F. Flanigin Department Surgery (Neurosurgery), Medical College of Georgia

Joseph R. Smith Department Surgery (Neurosurgery), Medical College of Georgia

Jennifer Dushku Office of Research Computers & Statistics, Medical College of Georgia

Harry Davis Office of Research Computers & Statistics, Medical College of Georgia

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Abstract

Hippocampal evoked potentials were recorded using the P3 tonal oddball paradigm in 30 patients with unilateral temporal lobe seizure focus. Spectral power of the evoked potentials was decreased on the side of seizure focus, but this reduction was much greater when the focus was on the left. The effect of left/right focus does not appear to be due to group differences in age, sex, seizure duration, or operative pathology. Remote or finer left/right structural differences or differential left/right hippocampal processing for the sequential tonal task are possible explanations.

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Differential Effects of Left Versus Right Seizure Focus on Human Hippocampal Evoked Responses

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Differential Effects of Left Versus Right Seizure Focus on Human Hippocampal Evoked Responses

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