Elevated VEGF concentrations in ascites and serum predict adverse prognosis in ovarian cancer

Abstract

Objective. To evaluate if serum and ascites VEGF-C concentration could be used as prognostic markers in ovarian cancer. Materials and methods. Serum and ascites VEGF-C were measured in 118 patients with ovarian cancer and 24 patients with benign gynaecological disease. ELISA method was employed to evaluate VEGF-C concentration. Results. Serum and ascites in ovarian cancer patients were higher than those in benign gynaecological disease (P < 0.0001). Serum VEGF-C and ascites VEGF-C were both correlated with FIGO stage, tumor grade, and lymph node metastasis (P < 0.05). Univariate analysis revealed that FIGO stage (P < 0.0001), tumor grade (P < 0.0001), lymph node metastasis (P < 0.0001), serum VEGF-C concentration (P = 0.0001), and ascites VEGF-C concentration (P < 0.0001) were significantly correlated with overall survival. Including these variables in a multivariate analysis revealed that VEGF-C concentrations in serum and ascites were independent predictors of shorter overall survival. Conclusion. Elevated VEGF-C concentrations in serum and ascites can be seen as the novel, widely available independent predictors of shorter overall survival in ovarian cancer.

Key Words::

• Biomarker
• lymphangiogenesis
• metastasis
• tumor
• vascular endothelial growth factor

Declaration of interest: The authors report no conflict of interest. The authors alone are responsible for the content and writing of the article.

This work was supported by a grant from the Liaoning Nature Science Fund (201102279).