Effects of electrical nerve stimulation on force generation, oxygenation and blood volume in muscles of the immobilized human leg

Abstract

Background. Transcutaneous electrical stimulation of the common peroneal nerve may be an additional clinical tool for enhancing venous return by active and passive mechanisms of muscle action in the immobilized leg. Purposes. To determine the effects of electrical stimulation of the common peroneal nerve to (1) produce force during isometric ankle joint dorsiflexion, and (2) alter muscle oxygenation and blood volume in the resting human leg. Methods. A novel electrical stimulator was applied to 28 legs of 14 healthy subjects. The force during isometric ankle joint dorsiflexion and myoelectric responses produced by stimulation-induced leg muscle contractions were investigated. Muscle oxygen saturation, blood volume and deoxygenated haemoglobin in the tibialis anterior and medial gastrocnemius muscles were measured by near-infrared spectroscopy during venous stasis (40 mmHg thigh tourniquet), with or without electrical stimulation. Results. The force produced during ankle joint dorsiflexion at the maximal stimulation intensity was 2.25 N (0.02–14.14) in the resting leg. Changes in muscle oxygen saturation during venous stasis, with or without electrical stimulation, were similar. Electrical stimulation during venous stasis caused 4–9% and 0.2–6% less increase in total muscle blood volume and deoxygenated hemoglobin compared to venous stasis alone. Conclusions. Nerve stimulation with a newly developed device partly counteracts increases in muscle blood volume and deoxygenated hemoglobin of the resting leg during venous stasis. Clinical relevance. The device stimulates active and passive mechanisms of leg muscle action that seems to enhance venous return in patients with impaired function.

Key Words::

• Electric stimulation
• muscle
• leg
• blood volume
• isometric contraction

Acknowledgments

We thank Ann-Christin Bengtsson for her help with the subjects.

Declaration of interest: The authors have no conflicts of interest. The authors alone are responsible for the content and writing of the paper.