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Scandinavian Journal of Clinical and Laboratory Investigation Volume 20, 1967 - Issue 2
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Original Article

Effects of Acute Respiratory Acidosis on Blood Lactate Concentration

K. Engel Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, USA
,
P. A. Kildeberg Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, USA
,
B. P. Fine Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, USA
&
R. W. Winters Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, USA
Pages 179-182 | Received 05 Jul 1967, Published online: 08 Jul 2009
 
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Abstract

The effect of acute hypercapnia upon blood lactate concentration has been studied in anesthetized, curarized dogs. In all experiments a significant and consistent fall in blood lactate to less than half the control value was demonstrated. These observations complement those demonstrating the well-known rise in blood lactate in alkalotic states and suggest that the effect of alteration of blood pH upon glycolysis extends to the acid range of pH values.

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