Decomposition of Iodine-Labelled Antipyrine

Abstract

The radiochemical stability of 4-iodoantipyrine-¹²³ and 4-iodo-antipyrine-¹²³I was examined under different circumstances by paper chromatography. The essential conclusions were (1) Use preferably the ¹²³I-labelled compound. (2) Dilute the compound with water and not with saline. (3) Analyse each batch for radiochemical purity. (4) Although temperature is not a major factor in the decomposition of 4-iodoantipyrine storage at the lowest convenient temperature is advisable. (5) Purify the ¹³¹I-labelled compound before use.

Key Words:

• Antipyrine
• idodine isotopes