Turnover of ¹³¹I-Labelled Ceruloplasmin in Rheumatoid Arthritis

Abstract

The distribution and turn-over kinetics of ceruloplasmin were studied by means of ¹³¹I-labelled human ceruloplasmin in 7 patients suffering from active rheumatoid arthritis and in 13 control subjects. Total mass and absolute intravascular mass showed a tendency towards higher values in the patients, though some overlapping was seen. No difference was seen in the distribution of ceruloplasmin in the intravascular and extravascular compartments in the patients and the control subjects. The fractional catabolic rate (per cent of intravascular pool per day) was on an average on the same level in the patients and the controls. The daily turnover was significantly accelerated in patients with rheumatoid arthritis.

Key Words:

• Ceruloplasmin
• iodine isotopes
• arthritis
• rheumatoid